We sat down with Dr. Alexis Denis, Ph.D. Medicinal Chemistry Director at Galapagos to collect his thoughts on the question: Should medicinal chemists use 3D molecular modeling tools?
We were able to understand how he manages the collaboration in SBDD teams, but also to understand his vision of how these positions/roles could evolve in the future.
Recently, our collaborative platform, 3decision, just saw itself complemented with two new features (subpocket search & interaction search) and a radically different User Experience (UX). This new UX, with an updated User Interface (UI), is the result of months of collaborative work between UserStudio and the 3decision team.
In order to tell the story of this project, we gathered people from both companies to answer a few questions.
If you’re struggling setting up Oracle materialized view that performs well on fast refresh, you may find answers in this post!
Read MoreA few days after the release of the new TIBCO Spotfire 10.10 LTS, we are glad to announce the availability of the Discngine Connector 5.4 for Spotfire and Pipeline Pilot. This new release is fully compatible with the newest versions of Spotfire (10.10) and Pipeline Pilot (2020)
Read MoreThe highly requested and long-awaited interaction search is finally here! Given the great amount of structural data we have at hand, the ability to mine ligand-protein complexes based on the interactions they create was a missing piece in our analytics toolbox.
Read MoreSelect a couple of amino acids in the binding site of your protein and retrieve, in a matter of minutes, other structures in the database which contain a similar subpocket. Similar meaning, similar features arranged similarly in 3D space. This is what the new subpocket search feature will allow you to do in the next release of 3decision!
Read MoreLast year, we set out a process to improve the user experience in 3decision. After years of gathering feedback and interviewing key users, we knew it was time to address the design and workflow flaws in the user interface. With the help of User Studio, an external UI/UX design company, we went through a deep refactoring and restyling of the front-end. The resulting work will be available in the next upcoming release of 3decision (3decision v2)!
Read MoreDiscngine is pleased to announce a partnership with I-Stem on the analysis of Covid-19 tests. As part of this collaborative work, Discngine supports IStem in designing the analysis of qPCR tests in Discngine Assay, identifying patients with COVID-19. We are proud to contribute to this joint effort.
Read MoreDiscngine is excited to announce a partnership with LabVoice. The partnership will focus on supporting the presence of voice assistants built for the laboratory and continue a shared vision of creating a more efficient, more compliant, and safer lab through the power of voice.
Read MoreWith the release of version 5.3 of the Discngine Connector we introduce a new feature: “Pipeline Pilot Calculated Columns”. Based on the Pipeline Pilot Data Function extension, it makes the data retrieval and transformation of Spotfire data columns with a Pipeline Pilot protocol simpler than ever.
Read MoreDiscngine announces that Sosei Heptares will use its 3decision® software to create an unprecedented structural GPCR chemogenomics platform. 3decision® will enable Sosei Heptares to combine public and proprietary structural data and derive unique GPCR structural insights.
Read MoreMy German cartesian mind (here we go with stereotypes) asks me to start with the first protein expressed by the viral genome of SARS-Cov-2, nsp1. That is, by far, not the low hanging fruit. But it is interesting to learn more about the roles of the different constituents of the virus. Nsp1 actually has also a few very interesting roles to facilitate the viral lifecycle in its host environment.
Read MoreThe bread and butter of every structure based drug design or drug ID effort is the need for 3D structural information of a target of interest related to the phenotypic outcome we want to alter. In the case of SARS-Cov-2 several experimental structures are already available in the RCSB PDB. Other a large scale fragment screens from the Diamond Light Source are slowly becoming available (available in the 3decision protease project for now) on public resources likes the RCSB PDB. Popular homology modelling services also already started to provide several high quality models for some of the yet not resolved structures of the viral proteome.
But let’s first have a look what the viral genome actually contains and what are currently pursued efforts.
Read MoreGabriella outlined in previous posts (part I & part II) a few things about SARS-Cov-2. Back at the time the crisis was still far away from our daily lives but things have changed dramatically during the last weeks. After our initial communication to make 3decision.discngine.cloud freely available for all Covid-19 related collaboration projects we were contacted independently by several volunteers from academic and industrial groups to collaborate on a global effort. At the mean time a lot of novel initiatives have seen the day and everybody is publishing blog posts (like I am right now), linkedIn articles, chemarxiv or bioarxiv preprints etc. It’s a little bit a scientific wild-west happening right now on a global scale.
Read MoreAt Discngine we are trying to provide the best services for our customers. In the pharmaceutical domain, we are led to help them to construct machine learning models for properties and biological activities prediction. Lately, we also tried various deep learning methods when it was possible...
Read MoreAs we explained in our previous article, the number of biomolecular structures available for computational analysis is increasing daily, which, for SBDD translates to ever-greater opportunities for discovery.
But wait, is that actually true?
Read MoreAs a follow-up to my previous article 2019-nCoV, structurally speaking, I thought I’d share some of the news on the protein structure side and some insights from the structural analyses we’ve done at Discngine.
Read MoreI guess nobody has missed the fact that we are in the middle of a new Coronavirus outbreak. In the beginning, I followed the updates from far, without going in too much detail. That was before I saw a LinkedIn post on a homology model of a 2019-nCoV protease last week.
Read MoreWe just released a new version of 3decision®. We've included new updates to Advanced Structural Search, Integrated Visualization & Collaboration. Check them out now!
Read MoreDiscover the challenges and opportunities in Structure-Based Drug Discovery (SBDD).
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